"The process of globalisation, which affects all our lives, is exerting a malign influence on football," said the head of world soccer's ruling body.
In a hard-hitting editorial in the November issue of the official FIFA magazine he is also critical of major clubs who abandon their roots and pack their teams with foreign players.
"A select few European clubs are increasingly desperate to appeal to international audiences in ever more distant parts of the globe to tap into new income streams that will allow them to continue to recruit what they regard as the "best" players.
"Since many such players hail from Africa, South America, Oceania and increasingly Asia, a high-stakes trade in humans is the end result," Blatter writes.
While he agrees some of the clubs in question already have international appeal either because of their playing success or the way they are marketed, Blatter objects to them abandoning their local social responsibilities.
Blatter's views are shared by UEFA, European soccer's governing body, which has been powerless to limit the number of foreigners playing for clubs since the so-called Bosman ruling removed restrictions in 1995.
UEFA is considering introducing new rules forcing clubs to include a minimum number of homegrown players developed through their own youth programmes.
But it is powerless to limit the number of foreigners coming through the youth ranks because of EU rules on free movement.
