The general council of the United Cricket Board of South Africa (UCBSA) confirmed it would not send a team to the event in the United Arab Emirates, because of the outbreak of hostilities.
The triangular tournament was due to be staged between Pakistan, Sri Lanka and South Africa.
Said the UCBSA's chief executive, Gerald Majola: "We value our players and officials and we cannot continue with the tour when there is concern about their safety.
"We received an advisory from the Department of Foreign Affairs informing us not to travel to the Gulf region under the current circumstances prevailing there.
"We are however, engaged in discussions with the tournament organisers as to possible alternative venues and or dates for the tournament to be held."
